Marburgvirus

Ron Smith, MD

Marburg in the News

(Fred Murphy, artificially colored initial image of Marburgvirus shown)


Thursday, 25 May 2023

Marburg virus ruled out in case of patient admitted to Valdecilla hospital in Santander


Friday, 21 April 2023

Twin Marburg virus outbreaks in Africa have global community on guard against further spread

At least 16 people in Equatorial Guinea, a tiny country on the Atlantic coast, as of mid-April. Eleven of those people have died. Tanzania, on the opposite coast, is dealing with its own outbreak of at least eight cases since late March.



Monday, 13 February 2023

Equatorial Guinea Confirms Country’s First Marburg Virus Outbreak


Monday, 30 January 2023

Marburg vaccine shows promising results in first-in-human study


Tuesday, 19 July 2022

Two Cases of Marburg Virus Confirmed in Ghana, 98 Suspected Contact Cases Currently in Quarantine


Saturday, 8 February 2020

Marburg virus identified in West African bats for the first time


Saturday, 8 February 2020

Marburg virus found in Sierra Leone bats


Wednesday, 16 June 2010

NIH-Supported Experimental Marburg Vaccine Prevents Disease Two Days after Infection

Quick Overview

History of Marburg

Under construction

Table of Ebola (EBV) Strains.

Kingdom: Riboviria, Phylum: Orthornavirae, Class: Negarnaviricota, Order: Monjiviricetes, Order: Mononegavirales, Family: Filoviridae, Genus: Ebolavirus, Species: (as shown below)

Year
1976
1976
1990
1994
2007
2019
Species
Zaire
Sudan
Reston
Taï Forest
Bundibugyo
Bombali
Acronym
EBOV
SUDV
RESTV
TAFV
BDBV
BOMV
Country
Yambuku, Congo (Zaire)
Nzara, South Sudan
Reston, Virginia, US
Parc National de Taï, Côte d'Ivoire
Bundibugyo, Uganda
Taita Hills, Kenya
Mortality
90%
50%
0%
0%
25%
Notes
The source in nature has yet to be identified.
SUDV/Bon (Bonaface) has ≤10% genomic difference, SUDV has ≥30% genomic difference from EBOV
This strain apparently originated in monkeys shipped from the Philippines and only kills primates, mild symptoms in man
Only 1 case, TAFV has ≥30% genomic difference from EBOV
Democratic Republic of the Congo
Found in captured Angolan free-tailed bat

Scrolling Table of Current & Past Occurrences of Marburgvirus (MARV) Infection.

Source: J. H. Kuhn, 2008, Filoviruses, p60-64.
Year
1967
1967
1967
1967
1975
1980
1982
1985
1987
1987-1992
1988
1988
1990
1990
1993
1994
Lake Victoria Marburg Samples
MARV-C167, MARV-Flak, MARV-Hartz, MARV-"L", MARV-Porton, MARV-Pop (Popinga), MARV-Rat (Ratayczak), MARV-Voe (Voege)
speculative
speculative
speculative
MARV-Cru (Cruickshank), MARV-Hogan, MARV-Ozo (Ozolin)
MARV-Mus (Musoke)
speculative
speculative
MARV-Ravn
speculativespeculative
MARV-"U" ("Variant U")
MARV-"V." ("V.")
speculative
speculative
speculative
speculative
Location
Germany (Marburg an der Lahn, Frankfurt am Main) & Yugoslavia (Belgrade)
Uganda
Germany (Marburg an der Lahh)
Germany (Biberach)
Rhodesian & South Africa (Johannesburg)
Kenya (Mt. Elgon & Nzoia)
Zimbabwe (Nyanda) & South Africa (Johannesburg)
Togo (Sodoke)
Kenya (Mombassa & Mt. Elgon)
Zaire (Durba, Watsa) - at least 3 independent outbreaks
U.S.S.R., R.S.F.S.R. (Koltsovo)
U.S.S.R., R.S.F.S.R. (Koltsovo)
U.S.S.R., R.S.F.S.R. (Koltsovo)
Kenya (Kitale) & Sweden (Linköping)
Kenya & Germany
Zaire (Durba, Watsa)
Cases
31
Epizootic
1
Epizootic
3
2
?
1
1
50 total
1
1
1
1
1
20
Deaths
7
0
1
1
0
1
1
1
0
1
8
Fatality %
7
0
33.3
50
0
100
100
100
0
100
40

How To Use The Marburgvirus Map.

When you do a search, all available information for each marker is compared to your search criteria. If you search for “Kenya” then the search will return both marker headings and descriptions that match. If you want to search only the marker labels, then use “Kenya;” instead. If you want to search for a particular strain of virus, then use the correct acronym. If you want to see outbreaks in a ceration year, then you can use “1976” or “1976.” to get the correct results.

Ebolavirus Vaccine

AfricaNews, 11/13/2019. The World Health Organization (WHO) on Tuesday approved a historic vaccine to combat Ebola virus. The drug called, Ervebo and manufactured by MERCK pharmaceuticals had until now been used in the Democratic Republic of Congo, DRC, as an experimental vaccine to the latest outbreak in the country’s east. The global health outfit said there is sufficient evidence that shows that the vaccine is effective. Ervebo effectively becomes the world’s first ever drug aimed at prevention of Ebola.

According to standards, a WHO prequalification is granted to a trial medication only after a drug passes important safety and efficacy tests. Experts have hailed the development as a crucial step that will accelerate access to and deployment in countries most exposed to Ebola epidemics.

The announcement follows the European Commission’s decision on Monday to authorise the marketing of this vaccine manufactured by the US laboratory Merck Sharpe and Dohme (MSD). Now, the various UN agencies and the Gavi Vaccination Alliance can obtain the vaccine “for countries at risk”.

Since the beginning of the epidemic in the DRC, which has killed some 2,190 out of more than 3,290 cases, over 236,000 people have been vaccinated with the first vaccine, according to WHO, including 60,000 health professionals.

A second vaccine, still experimental and developed by Johnson & Johnson, administered in two doses 56 days apart, is to be introduced in mid-November in areas where the virus is absent.

Academic Calendar

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